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Updated: Aug 30, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Detection of myocardial viability in acute infarction using contrast-enhanced (1)H magnetic resonance imaging

H B Hillenbrand1, J Sandstede, C Lipke

  • 1Cardiology Division, Department of Medicine, Julius-Maximilians Universität, Luitpold Krankenhaus, Josef-Schneider Strasse 2, 97080 Würzurg, Germany.

Magma (New York, N.Y.)
|October 2, 2003
PubMed
Abstract

Insights

Contrast-enhanced MRI identifies viable myocardium after acute myocardial infarction (MI). Areas without delayed enhancement accurately predict myocardial viability, aiding treatment decisions for chronic infarction.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Reperfusion therapies are crucial for salvaging myocardium at risk during acute myocardial infarction (MI).
  • Assessing myocardial viability post-MI is essential for guiding treatment strategies.
  • Delayed contrast enhancement on MRI is a key indicator in evaluating myocardial infarction.

Purpose of the Study:

  • To determine if areas without delayed MRI contrast enhancement in acute MI correlate with myocardial viability.
  • To assess the relationship between contrast-enhanced MRI findings and functional parameters like systolic wall thickening (%SWT) and end-diastolic wall thickness (EDWT) in chronic infarction.

Main Methods:

  • Twenty MRI studies were conducted on ten patients at two time points: within 6 days of MI and 3 months post-MI.
  • Myocardial segments were analyzed for viability using contrast-enhanced MRI, specifically looking for the absence of delayed enhancement.
  • %SWT and EDWT were measured in chronic infarction and compared with acute MI findings.

Main Results:

  • Of 1718 segments assessed in acute MI, 1333 showed no delayed enhancement and were considered viable.
  • All viable segments identified by MRI demonstrated %SWT at 90 days post-MI.
  • 97% of viable segments had EDWT > 5.5 mm; segments with partial viability (1-99%) also showed significant correlation with %SWT and EDWT.

Conclusions:

  • Contrast-enhanced MRI effectively identifies viable myocardium in acute reperfused MI, correlating with clinical viability parameters.
  • The absence of delayed MRI contrast enhancement is a reliable indicator of myocardial viability.
  • Delayed MRI contrast enhancement can help delineate non-transmural MI, serving as a valuable tool for planning revascularization procedures.

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