Related Experiment Video

Updated: Aug 17, 2026

Isolation of Brain-infiltrating Leukocytes
06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

[Polio-like myelitis due to Coxsackie-Virus B 3: Course under treatment with pleconaril]

N Utzig1, B Friedrich, C Burtzlaff

  • 1Ernst-Moritz-Arndt Universität Greifswald, Klinik für Kinder- und Jugendmedizin, Abteilung für Neuropädiatrie und Stoffwechselkrankheiten. utzi@uni-greifswald.de

Klinische Padiatrie
|October 2, 2003
PubMed

Insights

Severe enteroviral infections of the central nervous system, like myelitis, can be effectively treated with Pleconaril. This antiviral medication offers a promising option for patients with persistent enterovirus infections, leading to significant recovery.

Area of Science:

  • Neurology
  • Virology
  • Infectious Diseases

Background:

  • Enteroviruses frequently cause central nervous system (CNS) infections, including encephalitis and myelitis, with potential for severe outcomes.
  • Picornaviruses, such as enteroviruses and rhinoviruses, are responsible for a range of human diseases.
  • Pleconaril is an orally administered antiviral agent demonstrating broad activity against picornaviruses.

Observation:

  • A case study involved a 14-year-old girl with severe, polio-like myelitis and urinary incontinence attributed to Coxsackievirus infection.
  • The patient experienced a prolonged illness with persistent virus presence, necessitating intervention.
  • Treatment with Pleconaril was initiated due to the severity and persistence of the enteroviral CNS infection.

Findings:

  • Following Pleconaril treatment, the patient exhibited remarkable clinical improvement.
  • Key improvements included the restoration of urinary continency and the regained ability to walk unaided within weeks.
  • The case highlights the efficacy of Pleconaril in managing severe enteroviral CNS infections.

Implications:

  • The development of novel antiviral agents like Pleconaril expands therapeutic options for CNS infectious conditions.
  • This case underscores the importance of including enteroviruses in diagnostic workups for CNS infections.
  • Pleconaril represents a viable and effective treatment for enteroviral infections, particularly those affecting the central nervous system.

More Related Videos

Particle Agglutination Method for Poliovirus Identification07:06

Particle Agglutination Method for Poliovirus Identification

Published on: April 20, 2011

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-409:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...