Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A diagnostic cycle test for McArdle's disease.

John Vissing1, Ronald G Haller

  • 1Department of Neurology and Copenhagen Muscle Research Center, National University Hospital, Rigshospitalet, Copenhagen, Denmark. vissing@rh.dk

Annals of Neurology
|October 2, 2003
PubMed
Summary

The second wind phenomenon, characterized by decreased heart rate during exercise, is a specific indicator for McArdle

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Mitochondrial diseases].

Ugeskrift for laeger·2026
Same author

Long-term use of rozanolixizumab in generalised myasthenia gravis: final pooled analysis of the phase III MycarinG study and two open-label extensions.

Therapeutic advances in neurological disorders·2026
Same author

Health-related quality of life outcomes with nipocalimab versus placebo in generalized myasthenia gravis: an analysis of the Vivacity-MG3 study.

Journal of neurology·2026
Same author

Relative frequencies of muscle specific kinase antibody myasthenia in 46 centres worldwide.

Brain : a journal of neurology·2026
Same author

Clinical effectiveness of efgartigimod in a broad population of patients with generalized myasthenia gravis: subgroup analyses from a randomized, double‑blind, placebo‑controlled, phase 3 trial (ADAPT).

Journal of neurology·2026
Same author

Natural history of cardiac involvement in women carrying pathogenic DMD gene variants: a 7-year longitudinal study.

Journal of neurology·2026

Area of Science:

  • Exercise Physiology
  • Neuromuscular Disorders
  • Metabolic Myopathies

Background:

  • The second wind phenomenon, a decrease in heart rate and perceived exertion during sustained exercise, is not well understood.
  • Its potential as a diagnostic marker for specific conditions requires investigation.

Purpose of the Study:

  • To determine if the second wind phenomenon is pathognomonic for McArdle's disease.
  • To evaluate the diagnostic utility of exercise testing in identifying McArdle's disease.

Main Methods:

  • A comparative study involving patients with McArdle's disease, healthy controls, and patients with other inborn errors of muscle metabolism.
  • Participants underwent a 15-minute constant workload cycling test.
  • Heart rate and perceived exertion were monitored throughout the exercise period.

Main Results:

  • McArdle's disease patients exhibited a consistent decrease in heart rate during the latter stages of exercise (7th to 15th minute).
  • Control subjects (healthy and other metabolic myopathies) showed a progressive increase in heart rate.
  • The observed heart rate pattern was specific to McArdle's disease.

Conclusions:

  • Cycling at a moderate, constant workload is a specific, sensitive, and simple diagnostic test for McArdle's disease.
  • The second wind phenomenon, as observed in this study, is a valuable clinical sign for diagnosing McArdle's disease.

Related Experiment Videos