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Updated: Aug 30, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Retinal involvement in dementia with Lewy bodies: a clue to hallucinations?
Claude-Alain Maurage1, Marie-Magdeleine Ruchoux, Rob de Vos
1Department of Neuropathology, R. Salengro Hospital, CHRU, Lille Cedex, France. ca-maurage@chru-lille.fr
Abstract:
Visual hallucinations are a core feature of dementia with Lewy bodies. Their pathophysiology is not well understood, because neither clinical nor histological data have shown their basic mechanisms. Here, we report the presence of pale inclusions in the outer plexiform layer of the retina in a patient with dementia with Lewy bodies. These inclusions are related to cytoskeletal disorganization of the cones at ultrastructural level and modifications of the immunohistochemical pattern of distribution of synucleins in the retina. These modifications may participate in the visual impairment in dementia with Lewy bodies.
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