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[Effect of a compound preparation pumpan on exercise tolerance and clinical course of ischemic heart disease]

V B Krasnitskiĭ, D M Aronov, N I Zhidko

    Terapevticheskii Arkhiv
    |October 3, 2003
    PubMed

    Insights

    The drug pumpan, when added to standard therapy, reduced angina attacks and ST depression in patients with ischemic heart disease. This improves exercise tolerance for individuals with stable effort angina.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Ischemic heart disease (IHD) with stable effort angina (SEA) impacts exercise tolerance.
    • Functional class II-III patients experience significant symptoms impacting daily life.

    Purpose of the Study:

    • To evaluate the efficacy of the drug pumpan in improving exercise tolerance.
    • To assess pumpan's effect on exercise-induced myocardial ischemia in IHD patients.

    Main Methods:

    • A study involving 30 IHD patients with stable effort angina (functional class II-III).
    • Patients received standard antianginal therapy with or without the addition of pumpan.
    • Exercise tolerance and myocardial ischemia were assessed using bicycle ergometry.

    Main Results:

    • Pumpan addition to standard therapy significantly reduced the frequency of anginal attacks.
    • ST depression during bicycle exercise tests was notably decreased with pumpan.
    • Improved exercise tolerance was observed in the group receiving pumpan.

    Conclusions:

    • Pumpan demonstrates effectiveness as an adjuvant therapy for IHD patients with stable effort angina.
    • The drug aids in managing symptoms and improving exercise capacity in this patient group.
    • Pumpan can be a valuable addition to existing antianginal treatment regimens.
    Abstract

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