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Vascularization pattern in hypertrophic scars and keloids: a stereological analysis.
Thaís Amadeu1, André Braune, Carlos Mandarim-de-Lacerda
1Departamento de Histologia e Embriologia, Universidade do Estado do Rio de Janeiro, Brazil.
Pathology, Research and Practice
|October 3, 2003
Summary
Pathological scars like hypertrophic scars and keloids show distinct dermal vascularization patterns compared to normal skin. Abnormal blood vessel development is implicated in the formation of these abnormal scars.
Area of Science:
- Dermatology and Wound Healing
- Pathology
- Vascular Biology
Background:
- Wound healing can result in pathological scars, including hypertrophic scars and keloids.
- The role of vascularization in scar development is debated.
- Previous studies on scar vascularization lack consensus.
Purpose of the Study:
- To investigate and compare the dermal vascularization patterns in normal skin, normal scars, hypertrophic scars, and keloids.
- To determine if abnormal vascularization contributes to the pathogenesis of hypertrophic scars and keloids.
Main Methods:
- Stereological analysis of dermal vessels and myofibroblasts.
- Quantification of vessel surface and length density.
- Assessment of volume density in papillary and reticular dermis.
Main Results:
- No significant differences in vascularization between normal skin and normal scars.
- Increased vessel number in papillary dermis of hypertrophic scars and keloids versus normal skin.
- Hypertrophic scars exhibit more dilated vessels in the papillary dermis.
- Higher vessel density in the reticular dermis of hypertrophic scars and keloids compared to normal skin.
- No vascularization differences observed between hypertrophic scars and keloids.
Conclusions:
- Hypertrophic scars and keloids possess a unique dermal vascularization profile distinct from normal skin and scars.
- Abnormal vascularization is a significant factor in the development of hypertrophic scars and keloids.