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Related Experiment Videos

Lymph node findings in generalized mastocytosis.

H P Horny1, E Kaiserling, M R Parwaresch

  • 1Institute of Pathology, University of Tübingen, Germany.

Histopathology
|November 1, 1992
PubMed
Summary

Mast cell infiltrates are common in lymph nodes of generalized mastocytosis patients, often in medullary cords and sinuses. Malignant mastocytosis cases showed more eosinophilia, plasmacytosis, and fibrosis compared to systemic mastocytosis.

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Area of Science:

  • Hematology
  • Pathology
  • Oncology

Background:

  • Generalized mastocytosis involves abnormal mast cell accumulation.
  • Lymph node involvement is a key aspect of disease staging and prognosis.
  • Understanding lymph node micro-architecture in mastocytosis is crucial for diagnosis.

Purpose of the Study:

  • To histologically examine lymph nodes in generalized mastocytosis.
  • To identify mast cell infiltration patterns and micro-architectural changes.
  • To correlate findings with prognosis and disease subtypes.

Main Methods:

  • Histological analysis of lymph nodes from 21 generalized mastocytosis cases.
  • Assessment of mast cell infiltration, germinal center hyperplasia, vascular changes, and other pathological findings.

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  • Comparison of findings between systemic and malignant mastocytosis groups.

    • Main Results:

    • Mast cell infiltrates detected in 80% of lymph nodes, primarily in medullary cords and sinuses.
    • Frequent observations included germinal center hyperplasia (93%), blood vessel hyperplasia (93%), eosinophilia (53%), plasmacytosis (47%), and fibrosis (40%).
    • Leukemic infiltrates were exclusively found in malignant mastocytosis cases; eosinophilia, plasmacytosis, and fibrosis were significantly more common in malignant mastocytosis.

    Conclusions:

    • Lymph node histology reveals mast cell infiltration and reactive changes in generalized mastocytosis.
    • Distinct pathological features differentiate systemic from malignant mastocytosis.
    • Naphthol AS-D chloroacetate esterase staining is vital for diagnosing mast cell atypia in malignant mastocytosis.