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Heparin resistance.

Jayaram Bharadwaj1, Chandrasekhar Jayaraman, Rakesh Shrivastava

  • 1Department of Medicine, Unity Health System, Rochester, New York, USA.

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
|October 3, 2003
PubMed
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Heparin resistance affects up to 22% of patients, potentially causing serious complications. Awareness and alternative monitoring methods, like antithrombin III, are crucial for effective heparin therapy.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Cardiovascular Surgery

Background:

  • Heparin therapy is increasingly utilized across various clinical settings.
  • Achieving therapeutic anticoagulation promptly is essential for optimal patient benefit, especially during procedures like cardiopulmonary bypass and hemodialysis.
  • Heparin resistance, defined as the inability to achieve therapeutic anticoagulation, impacts a significant patient population.

Purpose of the Study:

  • To highlight the clinical significance of heparin resistance.
  • To emphasize the necessity of timely and appropriate management of heparin resistance.
  • To discuss strategies for preventing and managing heparin resistance, including the role of antithrombin III.

Main Methods:

  • Literature review on heparin therapy and resistance.

Related Experiment Videos

  • Analysis of clinical situations inducing heparin resistance.
  • Exploration of alternative monitoring methods for heparin therapy.

    • Main Results:

    • Heparin resistance has been reported in up to 22% of patients undergoing open-heart surgery.
    • Undercoagulation due to heparin resistance can lead to severe outcomes, ranging from subclinical coagulation to mortality.
    • Various common clinical situations can induce heparin resistance.

    Conclusions:

    • Awareness of heparin resistance is critical for preventing adverse events.
    • Prompt recognition and management of heparin resistance are necessary to avoid catastrophic consequences.
    • Antithrombin III administration is a recognized method for preventing heparin resistance.