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Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling
Published on: July 1, 2014
Facile and selective nanoscale labeling of peptides in solution by using photolabile protecting groups
Norman Koglin1, Manja Lang, Robert Rennert
1Institute of Biochemistry, University of Leipzig, Brüderstrasse 34, D-04103 Leipzig, Germany.
Abstract:
For the selective labeling of peptides, a novel strategy was developed that combines the advantages of solid-phase peptide synthesis with the flexibility of labeling reactions in solution. To direct a label at a distinct position within the peptide sequence, other reactive positions are blocked with photolabile protecting groups that could be easily removed after the labeling reaction. Therefore selective labeling may become feasible for the first time even in nanomol amounts.
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