Related Experiment Video
Updated: Aug 30, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Pharmacotherapy to limit weight gain caused by antipsychotic use
Gin S Malhi1, Philip B Mitchell
1The Mood Disorders Unit, The Villa, Prince of Wales Hospital, Randwick, NSW 2031, Sydney, Australia. g.malhi@unsw.edu.au
Abstract:
Obesity is a major health problem, especially in patients with severe mental illnesses. Newer atypical antipsychotics are better tolerated and have fewer extrapyramidal side effects, however, they can cause significant weight gain. This poses a considerable added burden and increases the likelihood of developing medical illnesses such as diabetes and cardiovascular disease. Obesity in patients taking antipsychotic medication can usually be avoided, if behavioural modification and pharmacological measures are implemented from the outset. Greater awareness and a willingness to address the problem are needed along with more research into the development of weight gain and its prevention. This review examines these issues with a pharmacotherapy focus.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Drug Therapy
Antianxiety Medications
Antidepressant Drugs: MAOIs and Other Agents
Psychosis and Antipsychotic Drugs: Overview
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Mania and Antimanic Drugs: Overview
