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Related Experiment Videos

Central nervous system abnormalities in migraine.

Dawn A Marcus1

  • 1Pain Evaluation & Treatment Institute, 5750 Centre Avenue, Pittsburgh, PA 15206, USA. dawnpainmd@yahoo.com

Expert Opinion on Pharmacotherapy
|October 3, 2003
PubMed
Summary

Migraine patients show brain structure and function changes, including white matter abnormalities. Research suggests mild cognitive issues between attacks, but more studies are needed to understand contributing factors.

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Area of Science:

  • Neuroscience
  • Neurology
  • Neuroimaging

Background:

  • Migraine is linked to central nervous system (CNS) structural and functional alterations.
  • White matter abnormalities are more common in migraineurs (16-40%).
  • Existing research indicates mild interictal (between attacks) cognitive dysfunction in migraine patients.

Purpose of the Study:

  • To explore the neuropsychological correlates of migraine and white matter abnormalities.
  • To identify interictal cognitive changes in migraineurs.
  • To clarify factors contributing to long-term cognitive changes.

Main Methods:

  • Review of existing studies on neuropsychological correlates of migraine.
  • Analysis of structural and functional CNS changes in migraineurs.
  • Examination of white matter abnormalities prevalence.

Main Results:

  • Migraine is associated with structural and functional CNS changes.
  • White matter abnormalities are prevalent in migraineurs.
  • Studies suggest mild interictal cognitive dysfunction.

Conclusions:

  • Further research is required to correlate migraine severity, frequency, and treatment with neuropsychological testing.
  • Future studies should investigate the impact of genetics, pain sequelae, and comorbid conditions on cognitive function.
  • Cognitive measures should be included as secondary endpoints in clinical trials.

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