Erythema dyschromicum perstans in prepubertal children

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Minimal Erythema Dose (MED) Testing
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Published on: May 28, 2013

Nanette B Silverberg1, Joshua Herz, Annette Wagner

  • 1St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA. nsilverberg@slrhc.org

Pediatric Dermatology
|October 3, 2003
PubMed

Insights

Erythema dyschromicum perstans (EDP) in children often resolves spontaneously within 2-3 years, unlike the adult form. This study found complete clearance in most pediatric patients, suggesting a different clinical course for childhood EDP.

Area of Science:

  • Dermatology
  • Pediatrics
  • Pigmentation Disorders

Background:

  • Erythema dyschromicum perstans (EDP) is a rare pigmentary disorder with an unclear etiology and clinical course in children.
  • Adult EDP typically has a slow onset and rarely resolves spontaneously.

Purpose of the Study:

  • To define the etiology and clinical course of childhood (prepubertal) Erythema dyschromicum perstans.
  • To compare the presentation and resolution of pediatric EDP with the adult form.

Main Methods:

  • Retrospective chart review and telephone interviews of eight pediatric patients diagnosed with EDP.
  • Analysis of clinical data including onset, duration, and treatment, with a focus on long-term follow-up.

Main Results:

  • Five of eight pediatric patients achieved complete resolution of EDP within an average of 2.5 years.
  • EDP onset in pediatric patients was noted between July and December.
  • Aminopenicillin administration was coincident with EDP development in two cases.

Conclusions:

  • Childhood (prepubertal) EDP demonstrates a distinct clinical course compared to adult EDP, with a high likelihood of spontaneous resolution within 2-3 years.
  • The findings suggest that pediatric EDP is a self-limiting condition, contrasting with the chronic nature often seen in adults.

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