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Updated: Aug 10, 2026
06:24
Minimal Erythema Dose (MED) Testing
Published on: May 28, 2013
Erythema dyschromicum perstans in prepubertal children
Nanette B Silverberg1, Joshua Herz, Annette Wagner
1St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA. nsilverberg@slrhc.org
Pediatric Dermatology
|October 3, 2003
Summary
Erythema dyschromicum perstans (EDP) in children often resolves spontaneously within 2-3 years, unlike the adult form. This study found complete clearance in most pediatric patients, suggesting a different clinical course for childhood EDP.
Area of Science:
- Dermatology
- Pediatrics
- Pigmentation Disorders
Background:
- Erythema dyschromicum perstans (EDP) is a rare pigmentary disorder with an unclear etiology and clinical course in children.
- Adult EDP typically has a slow onset and rarely resolves spontaneously.
Purpose of the Study:
- To define the etiology and clinical course of childhood (prepubertal) Erythema dyschromicum perstans.
- To compare the presentation and resolution of pediatric EDP with the adult form.
Main Methods:
- Retrospective chart review and telephone interviews of eight pediatric patients diagnosed with EDP.
- Analysis of clinical data including onset, duration, and treatment, with a focus on long-term follow-up.
Main Results:
- Five of eight pediatric patients achieved complete resolution of EDP within an average of 2.5 years.
- EDP onset in pediatric patients was noted between July and December.
- Aminopenicillin administration was coincident with EDP development in two cases.
Conclusions:
- Childhood (prepubertal) EDP demonstrates a distinct clinical course compared to adult EDP, with a high likelihood of spontaneous resolution within 2-3 years.
- The findings suggest that pediatric EDP is a self-limiting condition, contrasting with the chronic nature often seen in adults.
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