Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Digging deep--structure-function relationships in the melatonin receptor family.

Perry Barrett1, Shaun Conway, Peter J Morgan

  • 1Molecular Endocrinology Group, Division of Energy balance and Obesity, Rowett Research Institute, Aberdeen, UK. pb@rri.sari.ac.uk

Journal of Pineal Research
|October 3, 2003
PubMed
Summary

Researchers explored melatonin receptors (MT1, MT2) and the related melatonin receptor (MRR). Studies reveal insights into receptor function and may identify the ligand for the orphan MRR.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Daily torpor in the Djungarian hamster (Phodopus sungorus) is orchestrated by the suprachiasmatic nucleus: evidence from immediate early gene mapping and nucleus-specific sequencing.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2026
Same author

Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals.

eLife·2026
Same author

Single, but not mixed dietary fibers suppress body weight gain and adiposity in high fat-fed mice.

Frontiers in microbiology·2025
Same author

Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle.

iScience·2024
Same author

Resident gut microbiota community determines the efficacy of soluble fiber in reducing adiposity.

Frontiers in microbiology·2024
Same author

A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2023

Area of Science:

  • Pharmacology
  • Neuroscience
  • Molecular Biology

Background:

  • The melatonin receptor family, part of the G protein-coupled receptor (GPCR) superfamily, includes three subtypes that bind melatonin.
  • A related member, the melatonin receptor (MRR), shares significant sequence identity but does not bind melatonin.
  • Two subtypes, MT1 and MT2, are found in the mouse suprachiasmatic nucleus, with MT1 inhibiting neuronal firing and MT2 mediating melatonin's phase-advancing effects.

Purpose of the Study:

  • To investigate the structure-function relationships of mammalian melatonin receptors.
  • To develop subtype-specific compounds for melatonin receptors.
  • To potentially identify the ligand for the orphan melatonin receptor (MRR).

Main Methods:

  • Site-directed mutagenesis studies on melatonin receptors.

Related Experiment Videos

  • Chimeric receptor mutagenesis studies.

    • Main Results:

    • Mutagenesis studies provided insights into the structure-function relationships of melatonin receptors.
    • These studies may lead to the identification of the ligand for the orphan MRR.

    Conclusions:

    • Understanding melatonin receptor subtypes is crucial for developing targeted therapeutics.
    • Further research into melatonin receptor structure and function could unlock new therapeutic strategies.
    • The orphan MRR represents a potential new target for pharmacological intervention.