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Updated: Aug 30, 2026

Circadian Entrainment of Drosophila Melanogaster
Published on: June 3, 2020
Digging deep--structure-function relationships in the melatonin receptor family
Perry Barrett1, Shaun Conway, Peter J Morgan
1Molecular Endocrinology Group, Division of Energy balance and Obesity, Rowett Research Institute, Aberdeen, UK. pb@rri.sari.ac.uk
Abstract:
The melatonin receptor family is a small group of receptors within the G protein-coupled receptor (GPCR) superfamily. The group comprises of three subtypes which bind melatonin and one member, the melatonin related receptor (MRR), that shares >40% sequence identity with the other melatonin receptors but does not bind melatonin. Identification of two subtypes expressed in the mouse suprachiasmatic nucleus, one of which (MT1) inhibits neuronal firing and the other (MT2) mediating the phase advancing properties of melatonin has given renewed interest to the development of subtype specific compounds for each of the mammalian melatonin receptors. Towards this goal site-directed and chimaeric receptor mutagenesis studies have been performed which have provided some insight into the structure-function relationships of the melatonin receptors. Furthermore, these studies may lead to the identification of the ligand for the orphan MRR.
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