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Updated: Aug 30, 2026

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Published on: November 14, 2017
[A study on genetic epidemiology of cerebral infarction]
Bao-lin Shi1, Yong Zhang, Yan-hua Wu
1The Public Health Section, Zhangjiakou Medical College, Zhangjiakou 075029, China.
Objective:
To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.
Methods:
A matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction.
Results:
The prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 (0.113 0 - 0.174 4), significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84% and 40.95% higher in male's than in female's.
Conclusion:
Cerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males.
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