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Updated: Aug 30, 2026
Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
Published on: March 26, 2015
In vitro evaluation of combined graft deformation in anterior cruciate ligament reconstructions
Nicola Hagemeister1, Jacques A de Guise
1Laboratoire de recherche en imagerie et orthopédie, Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame 1st Floor, Room Y-1614 1650 Sherbrooke Street East, Montreal, QC H2L 4M1, Canada. nicola.hagemeister@etsmtl.ca
Abstract:
In this paper, we present a simple method of calculating deformation of an anterior cruciate ligament graft in combined elongation, bending and total twisting. We also report our results on these deformations for three types of ligament reconstruction in cadaver knees: two isometric reconstructions, using either a biological bone-patellar tendon-bone autograft or an artificial Trevira prosthesis, and modified over-the-top reconstruction with the prosthesis. The data show that the modified OTT technique produced elongation of the graft equivalent to that of the synthetic isometric technique, but significantly less than isometric reconstruction with the biological graft (p<0.05, ANOVA). Moreover, the grafts were subjected to bending and twisting.