Estimating residual stromal thickness before and after laser in situ keratomileusis

To determine the factor(s) that influences measurement of residual stromal thickness (RST) after laser in situ keratomileusis (LASIK) surgery.

Clinical office-based excimer laser refractive surgery center.

In this retrospective comparative interventional case study of 6235 eyes, ultrasonic corneal pachymetry was performed immediately before and after flap creation and immediately after laser ablation in the primary procedure and after 647 enhancements. Differences in the methods for calculating RST were compared statistically.

Using the RST measured at enhancement as the actual RST, measurements of RST immediately after laser ablation underestimated residual thickness due to laser-induced stromal dehydration and microkeratome effects (P<.001). Estimates of RST using a "standard" or estimated flap thickness were less accurate predictors of residual thickness (P<.001) than use of the theoretical laser resection with a measured flap thickness (RST-4) (P =.78) or a modified flap thickness subtracted from the postoperative corneal thickness (RST-8) (P =.98), which provided the best RST estimates.

Before LASIK, the best means of estimating RST is to subtract the theoretical laser resection obtained from the laser computer and the expected flap thickness normally obtained with a given microkeratome system from the preoperative central corneal thickness. After LASIK, the most accurate means of calculating RST is to subtract the original flap thickness from the postoperative central corneal thickness.