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Related Experiment Videos

Scrapie and experimental BSE in sheep.

Nora Hunter1

  • 1Neuropathogenesis Unit, Institute for Animal Health, Edinburgh, UK.

British Medical Bulletin
|October 3, 2003
PubMed
Summary

Scrapie and Bovine spongiform encephalopathy (BSE) are compared in sheep, a natural host for scrapie. Sheep PrP genotype influences susceptibility, and BSE infection is detectable in blood, aiding safety studies.

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Area of Science:

  • Veterinary medicine
  • Neurodegenerative diseases
  • Prion diseases

Background:

  • Scrapie naturally affects sheep and can be experimentally transmitted.
  • Bovine spongiform encephalopathy (BSE) affects cattle, but has infected humans and can transmit to sheep orally.
  • Concerns exist about natural BSE infection in UK sheep, necessitating comparative studies with scrapie.

Purpose of the Study:

  • To compare scrapie and BSE pathogenesis in sheep.
  • To investigate the role of PrP genotype in sheep susceptibility to scrapie and BSE.
  • To evaluate the potential of PrP(Sc) deposition as an infection marker for BSE in sheep.

Main Methods:

  • Experimental inoculation and oral dosing of sheep with scrapie and BSE.
  • Analysis of PrP genotype in relation to disease susceptibility.
  • Monitoring for PrP(Sc) deposition as an indicator of infection.
  • Detection of BSE infection markers in sheep blood.

Main Results:

  • PrP genotype is a key factor in sheep susceptibility and resistance to both scrapie and BSE.
  • BSE infection in sheep is detectable in the blood.
  • PrP(Sc) deposition serves as a marker for identifying BSE-infected animals and understanding pathogenesis.

Conclusions:

  • Comparative studies of scrapie and BSE in sheep are crucial for understanding prion disease transmission and pathogenesis.
  • Sheep models are vital for studying BSE and its implications for human health, particularly concerning blood product safety.

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