Related Experiment Video
Updated: Jun 25, 2026

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
Published on: February 11, 2009
Selectin and selectin ligand binding: a bittersweet attraction
Thomas M Zollner1, Khusru Asadullah
1Corporate Research Business Area Dermatology, Schering AG, Muellerstrasse 178, D-13342 Berlin, Germany. Thomas.Zollner@Schering.de
Abstract:
Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies. An important study may now open new avenues in this exciting field of anti-inflammatory therapies by introducing a putative inhibitor of poly-N-acetyllactosamine biosynthesis that affects selectin ligand activity and shows efficacy in a rodent skin inflammation model.
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