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Exercise and intestinal polyp development in APCMin mice.

Lisa H Colbert1, Volker Mai, Susan N Perkins

  • 1National Institute on Aging/NIH, Bethesda, MD 20892, USA.

Medicine and Science in Sports and Exercise
|October 3, 2003
PubMed
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Physical activity reduced polyp development in male mice but not females, despite favorable body composition changes. This study investigated exercise and sex interactions on polyp formation in APCMin mice.

Area of Science:

  • Oncology
  • Exercise Physiology
  • Genetics

Background:

  • Epidemiological studies indicate physical activity may protect against colon cancer.
  • Previous research in APCMin mice suggested fewer polyps in exercised males, but not females.
  • This study aimed to further explore the exercise and sex interaction on polyp development and underlying mechanisms.

Purpose of the Study:

  • To investigate the impact of regular treadmill running on polyp development in male and female APCMin mice.
  • To examine the interaction between exercise and sex on intestinal polyp formation.
  • To explore potential physiological mechanisms linking exercise, sex, and polyp development.

Main Methods:

  • APCMin mice (N=120, 60 males, 60 females) were assigned to exercise (treadmill running) or control groups.

Related Experiment Videos

  • Exercise involved treadmill running for 8 weeks.
  • Body weight, body composition, fasting glucose, leptin, insulin-like growth factor-1, and urinary corticosterone were measured. Polyp number and size were assessed at sacrifice.

    • Main Results:

    • Exercise led to lower body weight and reduced fat mass in both sexes.
    • Fasting glucose and leptin levels were significantly lower in exercised mice.
    • While total polyp number and size were not significantly different, exercised males showed fewer jejunal polyps compared to controls, an effect more pronounced in consistent runners.

    Conclusions:

    • Eight weeks of running induced favorable physiological changes, including improved body composition and metabolic markers.
    • Exercise demonstrated a modest protective effect on polyp development in male APCMin mice, specifically in the jejunum.
    • No significant effect of exercise on polyp development was observed in female APCMin mice, highlighting a potential sex-specific response.