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Plasma-cell homing.

Eric J Kunkel¹, Eugene C Butcher

¹Bioseek, Inc., Burlingame, California 94010, USA. ejkunkel@cmgm.stanford.edu

Nature Reviews. Immunology

|October 3, 2003

Summary

This summary is machine-generated.

Chemokines guide antibody-secreting cells (ASCs) to specific tissues. This directed migration influences the effectiveness of mucosal, inflammatory, and systemic antibody responses.

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Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

Antibody-secreting cells (ASCs) migrate from lymphoid tissues to effector sites.
This migration is crucial for effective humoral immunity.
Chemokines and adhesion molecules orchestrate this cellular trafficking.

Purpose of the Study:

To investigate the role of chemokines in directing ASC migration.
To understand how ASCs target specific tissues like mucosal surfaces, inflamed areas, and bone marrow.
To elucidate the impact of chemokine-mediated homing on antibody response characteristics.

Main Methods:

Analysis of chemokine receptor expression on developing ASCs.
Tracking of ASC migration patterns in response to chemokine gradients.

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Correlation of ASC homing with antibody production sites.

Main Results:

Developing ASCs alter chemokine receptor expression.
Upregulation of specific chemokine receptors directs IgA ASCs to mucosal sites.
IgG ASCs are directed to inflammatory sites, and both ASC types to bone marrow.
Chemokine-driven homing influences the nature of antibody responses.

Conclusions:

Chemokines are key regulators of ASC homing to distinct tissue compartments.
Targeted ASC migration by chemokines is essential for efficient mucosal, inflammatory, and systemic antibody production.
Understanding chemokine-mediated homing provides insights into immune response regulation.