Related Experiment Video
Updated: Aug 30, 2026

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
Published on: February 10, 2018
Histopathological features of L-asparaginase-induced liver disease
1Department of Pathology, The University of Chicago Hospitals, Chicago, Illinois, USA.
Abstract:
We studied the histopathological changes of liver in four patients who developed hepatomegaly and abnormal liver chemistry tests 2 to 20 days following administration of L-asparaginase as a part of a combination chemotherapy regimen for treatment of acute lymphoblastic leukemia. The severity of the liver disease due to L-asparaginase was unpredictable. One patient developed acute fulminant hepatic failure and required liver transplantation. The most consistent pathological change, observed in all four cases, was diffuse steatosis. Other changes included patchy hepatocyte necrosis, mixed inflammatory cell infiltrates in the portal tracts, and variable degrees of hepatocellular, or canalicular cholestasis, or a combination of these.
More Related Videos
Related Concept Videos
Cirrhosis II: Pathophysiology
Liver Histology
Hepatocytes perform a variety of essential functions. They secrete...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cirrhosis I: Introduction
Lysosomal Hydrolases

