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Related Experiment Videos

Recurrent invasive pneumococcal disease: a population-based assessment.

Mark D King1, Cynthia G Whitney, Falgunee Parekh

  • 1Emory University School of Medicine, Atlanta, GA 30303, USA. mking3@emory.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 3, 2003
PubMed
Summary

The risk of recurrent invasive pneumococcal disease (IPD) is high, especially for individuals with HIV and young children with chronic illnesses. Most patients experiencing IPD recurrence had a clear indication for pneumococcal vaccination.

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Invasive pneumococcal disease (IPD) poses a significant public health threat.
  • Understanding recurrence risk is crucial for effective disease prevention and management.

Purpose of the Study:

  • To determine the recurrence rate of IPD.
  • To identify characteristics of individuals at higher risk for recurrent IPD.

Main Methods:

  • Population-based surveillance using data from the US Centers for Disease Control and Prevention's Active Bacterial Core Surveillance.
  • Definition of recurrent IPD as isolation of Streptococcus pneumoniae from a sterile site ≥30 days after the initial positive culture.
  • Multivariable analysis to identify risk factors for recurrence.

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Main Results:

  • Among 13,924 survivors of initial IPD, 318 (2.3%) experienced 376 recurrences.
  • The IPD recurrence rate was 1294 episodes per 100,000 person-years, 50 times the annual incidence.
  • Higher recurrence risk was observed in individuals with human immunodeficiency virus (HIV) and children under 5 years old with chronic illness.
  • 92% of individuals with recurrence had a documented vaccine indication.

Conclusions:

  • The risk of IPD recurrence is substantial in specific populations.
  • Individuals with HIV and young children with chronic illnesses are particularly vulnerable to IPD recurrence.
  • Vaccination strategies may need to be optimized for high-risk groups to prevent recurrent IPD.