Related Experiment Video
Updated: Aug 30, 2026

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
Published on: September 6, 2015
The significance of routine serum magnesium determination in the ED
1Emergency Department, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Abstract:
To determine the significance of routine serum magnesium determination in the ED, a retrospective analysis was done on 253 patients in whom serum magnesium levels were examined in the department of EM. Mild, moderate, and severe hypomagnesemia was found in 19.5%, 9.1%, and 2.5% of the study population, respectively. Univariate analysis showed that pregnancy and pregnancy-related conditions, diabetes mellitus, gender, renal function, infectious diseases, and the presence of ischemic heart disease were associated with low serum magnesium levels. In multivariate analysis, only pregnancy and pregnancy-related conditions (odds ratio [OR], 4.39; 95% confidence interval [CI], 1.2-15.3) and diabetes mellitus (OR, 9.04, 95% CI, 3.3-24.75) were significantly associated with low serum magnesium levels. The number of patients admitted to the hospital and the number of patients who died was not statistically significantly different between the groups of patients with normal serum magnesium levels as compared with those with low serum magnesium levels. Although hypomagnesemia was found in 31% of the study population, its clinical significance is not clear given the absence of hypomagnesemia-related complications and death.
Related Concept Videos
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Complexometric EDTA Titration Curves
EDTA: Direct, Back-, and Displacement Titration
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides and...
Serum Studies: Renal Function Tests
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
