Related Experiment Video

Updated: Aug 30, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

[Tuberculin sensitivity in infants and preschool children with pulmonary tuberculosis]

V M Mel'nik, L I Mykolyshin

    Problemy Tuberkuleza I Boleznei Legkikh
    |October 4, 2003
    PubMed

    Insights

    Tuberculin skin test sensitivity in young children with tuberculosis varies by age and disease severity. Infants show more negative reactions, while severe or complicated TB is linked to reduced sensitivity.

    Area of Science:

    • Pediatric Infectious Diseases
    • Immunology
    • Tuberculosis Research

    Context:

    • Tuberculin skin testing (TST) is a key diagnostic tool for tuberculosis (TB).
    • Understanding TST reactivity in young children is crucial for accurate TB diagnosis and management.
    • Factors influencing TST results in pediatric TB require further elucidation.

    Purpose:

    • To investigate the tuberculin sensitivity patterns in children under 7 years old diagnosed with tuberculosis.
    • To analyze the relationship between TST results and patient age, TB form, disease severity, complications, and comorbidities.

    Summary:

    • TST reactivity in children under 7 with TB was assessed.
    • Infants (<3 years) exhibited significantly higher rates of negative TST reactions (13.2x) and lower rates of hyperergic reactions (5.8x) compared to older children (3-7 years).
    • Negative TST results correlated with complicated, severe TB, and comorbidities. Hyperergic reactions were noted in ocular TB (44.5%), helminthic infections (30.4%), and resolving pulmonary TB (32.4%).

    Impact:

    • Findings highlight age-related differences in TST response in pediatric TB.
    • Identifies clinical factors associated with altered TST reactivity, aiding in TB diagnosis and prognosis in young children.
    • Provides insights into immune responses in pediatric TB, informing clinical practice and further research.

    More Related Videos

    A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo11:17

    A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

    Published on: August 11, 2018

    Related Concept Videos

    Pulmonary Tuberculosis IV01:26

    Pulmonary Tuberculosis IV

    Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
    Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
    Pulmonary Tuberculosis III01:31

    Pulmonary Tuberculosis III

    Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
    The first classification is based on the development of the disease, and it includes the following categories:
    Pulmonary Tuberculosis I01:29

    Pulmonary Tuberculosis I

    Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
    Causative Organism
    The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
    Mode of...
    Pulmonary Tuberculosis V01:28

    Pulmonary Tuberculosis V

    Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
    Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
    Pulmonary Tuberculosis II01:28

    Pulmonary Tuberculosis II

    Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
    Here is a detailed explanation of its pathophysiology:
    Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
    Tuberculosis01:23

    Tuberculosis

    Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...