Related Experiment Video
Updated: Aug 30, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
[Nasal mucosa in patients with diabetes mellitus]
Maciej Müller1, Stanisław Betlejewski
1Klinika Otolaryngologii AM im. L. Rydygiera w Bydgoszczy.
Abstract:
Diabetes mellitus is the most common endocrinologic disease all over the world. 150 million people suffer from this disease, in Poland about 2 million. The disease on the basis of the onset and pathophysiology may be divided into type I and type II. Pathophysiologic changes include diabetic microangiopathy, macroangiopathy and neuropathy. The most common presentations in head and neck are otitis externa, hypoacusis, vertigo, disequilibrium, xerostomia, dysphagia, fungal and recurrent infections. The changes in nasal mucosa are not very well known. Only few papers concerned the problem. The main complaints of patients regarding the nose are xeromycteria, hyposmia and various degree of decreased patency of the nose. Chronic atrophic rhinitis, septal perforation, ulceration of nasal mucosa, alar necrosis, symptoms of staphylococcal or fungal infection can be found during otolaryngologic examination. The treatment in this group of patients should consist of systemic therapy of diabetes mellitus and on the other hand focal therapy with the use of a solution to moisten the nasal mucosa.
Insights
Diabetes mellitus, a common endocrine disease, affects millions globally. This study details its less-understood effects on nasal mucosa, including xeromycteria and hyposmia, and suggests targeted treatments.
Area of Science:
- Endocrinology
- Otolaryngology
Context:
- Diabetes mellitus is a prevalent global endocrinologic disease affecting 150 million people worldwide, with 2 million in Poland.
- Pathophysiologic changes associated with diabetes include microangiopathy, macroangiopathy, and neuropathy.
- While head and neck manifestations are documented, nasal mucosa changes in diabetic patients are less understood.
Purpose:
- To explore the less-documented effects of diabetes mellitus on nasal mucosa.
- To identify common nasal complaints and otolaryngologic findings in diabetic patients.
- To propose treatment strategies for nasal complications in diabetes.
Summary:
- Diabetes mellitus can lead to nasal symptoms such as xeromycteria (dryness), hyposmia (reduced smell), and nasal obstruction.
- Otolaryngologic examination may reveal chronic atrophic rhinitis, septal perforation, mucosal ulceration, alar necrosis, and infections (staphylococcal, fungal).
- Treatment involves optimizing systemic diabetes management and local nasal care, including moisturizing solutions.
Impact:
- Highlights the importance of recognizing and managing nasal complications in diabetic patients.
- Contributes to a better understanding of diabetes-related head and neck manifestations.
- Provides a basis for improved patient care and targeted therapeutic interventions for nasal issues in diabetes.
Related Concept Videos
Diabetic Neuropathy
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type I Diabetes III: Clinical Manifestations
Diabetes: Symptoms, Diagnosis, and Complications
Diabetic Retinopathy
Diabetic Nephropathy

