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Marmoset models commonly used in biomedical research.

Keith Mansfield1

  • 1New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, Massachusetts 01772, USA.

Comparative Medicine
|October 4, 2003
PubMed
Summary

The common marmoset (Callithrix jacchus), a Brazilian primate, is increasingly used in biomedical research, offering advantages over traditional nonhuman primates. Its availability and unique physiology make it a valuable alternative for drug development and safety assessments.

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Area of Science:

  • Primate models in biomedical research
  • Comparative physiology
  • Drug discovery and safety assessment

Background:

  • The common marmoset (Callithrix jacchus) is a small, nonendangered New World primate native to Brazil.
  • Historically utilized in neuroscience, reproductive biology, infectious disease, and behavioral research.

Purpose of the Study:

  • To present marmoset models commonly used in biomedical research.
  • To highlight their potential as an alternative to traditional nonhuman primate species.

Main Methods:

  • Review of historical and recent applications of common marmosets in research.
  • Emphasis on models offering alternatives to traditional nonhuman primates.

Main Results:

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  • Common marmosets are increasingly employed in drug development and safety assessment.
  • Advantages include size, cost, husbandry, biosafety, and unique physiological traits.
  • Ease of captive breeding and availability support their use.

    • Conclusions:

    • Common marmosets offer a viable alternative to traditional nonhuman primates in various research fields.
    • Their unique characteristics and practical advantages facilitate their integration into biomedical research models.