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Persistent mammary hyperplasia in FVB/N mice
Ana I Nieto1, G Shyamala, Jose J Galvez
1Departamento de Patologia Animal II, Facultad de Veterinaria, Cuidad Universitaria, 28040 Madrid, Spain.
Comparative Medicine
|October 4, 2003
Summary
Multiparous FVB/N female mice frequently develop persistent mammary hyperplasia after pregnancies. This background condition, unrelated to pituitary abnormalities, is crucial for interpreting transgenic mouse studies.
Area of Science:
- * Mouse genetics and pathology
- * Reproductive biology and endocrinology
Background:
- * The FVB/N mouse strain is a common model for generating transgenic mice.
- * Persistent mammary hyperplasia has been observed in multiparous FVB/N females.
- * Previous observations lacked detailed experimental data.
Purpose of the Study:
- * To experimentally evaluate mammary gland changes in FVB/N mice under controlled conditions.
- * To confirm the incidence and characteristics of persistent mammary hyperplasia in relation to parity.
Main Methods:
- * Evaluation of mammary glands from 10 multiparous FVB/N female mice from the Lawrence Berkeley National Laboratory (LBNL) colony.
- * Image analysis to estimate the percentage of fat pad filling.
- * Assay of serum and pituitary gland samples for prolactin concentration.
Main Results:
- * Multiparous FVB/N females consistently exhibited persistent mammary hyperplasia.
- * Four of seven females showed hyperplasia after three pregnancies.
- * Sporadic squamous nodules and mammary carcinomas were observed.
Conclusions:
- * Parity-related persistent mammary hyperplasia is a common phenotype in FVB/N mice.
- * This hyperplasia can occur without detectable pituitary abnormalities.
- * These background findings are essential for interpreting genetic manipulation studies in FVB/N mice.