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Related Experiment Videos

Toward ambulatory arteriovenous CO2 removal: initial studies and prototype development.

Dongfang Wang1, Scott Lick, Scott K Alpard

  • 1Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555-0528, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 4, 2003
PubMed
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Ambulatory arteriovenous carbon dioxide removal (AVCO2R) uses an 8 mm graft for optimal blood flow. This enables a new ultra-low resistance gas exchanger to achieve near-total CO2 removal, supporting lung rest and potential survival improvements.

Area of Science:

  • Cardiovascular Engineering
  • Respiratory Physiology
  • Medical Device Development

Background:

  • Extracorporeal arteriovenous carbon dioxide removal (AVCO2R) offers lung rest and improved survival.
  • Current AVCO2R systems are not designed for patient ambulation.
  • Severe chronic obstructive pulmonary disease (COPD) and pre-lung transplant rehabilitation are potential applications for ambulatory AVCO2R.

Purpose of the Study:

  • To identify the optimal ambulatory access for AVCO2 removal.
  • To develop a prototype gas exchanger for ambulatory AVCO2R.

Main Methods:

  • Gore-Tex grafts (6 mm and 8 mm) were anastomosed to sheep carotid arteries and jugular veins to assess blood flow.
  • Graft blood flow was measured under various conditions.

Related Experiment Videos

  • A prototype ultra-low resistance, pumpless gas exchanger was developed and connected to PTFE loops for ambulatory AVCO2R testing.

    • Main Results:

    • Transected 8 mm Gore-Tex grafts achieved up to 2000 ml/min blood flow, exceeding requirements.
    • The prototype Ambulatory-AVCO2R gas exchanger demonstrated an average pressure gradient of 2.8 +/- 0.8 mm Hg.
    • Mean CO2 removal was 104.8 +/- 14.0 ml/min at an average blood flow of 900 ml/min.

    Conclusions:

    • An 8 mm Gore-Tex reinforced graft arteriovenous loop provides sufficient blood flow for ambulatory AVCO2R.
    • The developed ultra-low resistance gas exchanger effectively achieves near-total CO2 removal during ambulation.