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Related Experiment Videos

Using computational fluid dynamics software to estimate circulation time distributions in bioreactors.

Kyle M Davidson1, Shrinivasan Sushil, Charles D Eggleton

  • 1Department of Mechanical Engineering, 1000 Hilltop Circle, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA.

Biotechnology Progress
|October 4, 2003
PubMed
Summary

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Computational fluid dynamics (CFD) software can characterize circulation time distributions (CTD) in fermentation mixing tanks. This study demonstrates CFD

Area of Science:

  • Biochemical Engineering
  • Fluid Dynamics
  • Process Engineering

Background:

  • Nonideal mixing in fermentation leads to gradients affecting cellular behavior and yield.
  • Circulation time distribution (CTD) quantifies exposure frequency to these gradients.
  • Experimental CTD determination is challenging and sparsely documented.

Purpose of the Study:

  • To evaluate computational fluid dynamics (CFD) software for characterizing CTD in a single-impeller mixing tank.
  • To compare CFD-simulated CTDs with experimentally determined CTDs.
  • To explore potential for CFD in developing novel signal processing methods for CTD analysis.

Main Methods:

  • CFD simulations were performed using FLUENT 4 and MixSim software.
  • Flow fields in three mixing tanks were simulated using the kappa-epsilon turbulence model.

Related Experiment Videos

  • Tracer particle trajectories were simulated to calculate return times to a reference zone.

    • Main Results:

    • CFD simulations successfully captured characteristic features of experimentally measured CTDs, including log-normal, bimodal, and unimodal distributions.
    • Simulations reproduced signal processing procedures from experimental measurements.
    • CFD data indicated potential for new signal processing methods predicting unimodal CTDs across tested tanks.

    Conclusions:

    • CFD is a viable tool for characterizing CTD in mixing tanks.
    • CFD simulations can accurately replicate experimental CTD features.
    • CFD offers a promising approach for developing advanced signal processing techniques for fermentation process analysis.