[Refractory nature of erythrocytes and thrombocytes]

The authors studied the influence of proteolytic enzymes and arachidonic acid on the erythrocyte and platelet aggregation. These substances stimulated the blood formed elements aggregation. At the same time preliminary incubation of fibrinolysin, trypsin and arachidonic acid with the blood formed elements suspension was accompanied by a significant reduction of their aggregation capacity, i.e. by the development of a refractory condition. A possible mechanism of this phenomenon is discussed.