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Related Experiment Videos

Will MAC be back?

Stephen Salerno1, Patricia Terrill

  • 1Plastic Surgery Unit, Frankston Hospital, Monash University, Melbourne, Victoria, Australia. salerno@netspace.net.au

ANZ Journal of Surgery
|October 4, 2003
PubMed
Summary
This summary is machine-generated.

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Standard local excision effectively treats microcystic adnexal carcinoma (MAC) when margins are at least 4 mm. This aggressive cancer requires careful monitoring, even with clear margins, due to its invasive nature.

Area of Science:

  • Dermatology
  • Surgical Oncology
  • Pathology

Background:

  • Microcystic adnexal carcinoma (MAC) is an aggressive skin cancer known for local invasion and perineural spread.
  • Historically, Mohs micrographic surgery has been favored for MAC due to concerns about achieving clear margins.
  • Limited evidence exists comparing standard local excision with Mohs surgery for MAC outcomes.

Purpose of the Study:

  • To evaluate the efficacy of standard local excision in achieving tumor clearance for MAC.
  • To assess recurrence rates and margin status in patients treated with local excision for MAC.

Main Methods:

  • Retrospective review of 17 patients diagnosed with MAC and treated with local excision.
  • Histopathological review of surgical specimens by dermatopathologists.

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  • Analysis of patient demographics, follow-up duration, margin status, and recurrence.

    • Main Results:

    • Two of 17 patients experienced recurrence after standard local excision.
    • Recurrence was observed in 2 of 3 patients with lateral margins < 4 mm, both with perineural invasion.
    • Mean follow-up was 30 months; mean lateral and depth margins were 7.69 mm and 4.66 mm, respectively.

    Conclusions:

    • Standard local excision can be effective for MAC clearance if lateral margins are ≥ 4 mm.
    • Perineural invasion is a critical factor associated with recurrence in MAC.
    • Longer follow-up is necessary to fully assess outcomes due to MAC's aggressive, locally invasive nature.