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Postprandial lipemia and cardiovascular disease
Dianne Hyson1, John C Rutledge, Lars Berglund
1Department of Medicine, University of California, Davis, 4150 V Street, Suite G400, Sacramento, CA 95817, USA.
Current Atherosclerosis Reports
|October 4, 2003
Summary
Postprandial lipemia, a rise in blood fats after meals, is linked to atherosclerosis risk. Managing this condition may help prevent heart disease progression.
Area of Science:
- Cardiovascular Science
- Metabolic Health
Background:
- Postprandial lipemia, elevated blood lipids post-meal, is a common metabolic state.
- Evidence links this condition to increased risk of atherosclerosis.
- Humans spend most of their time in this dynamic, nonsteady-state condition.
Purpose of the Study:
- To review the evidence linking postprandial lipemia to atherogenesis.
- To highlight the adverse effects of triglyceride-rich lipoproteins.
Main Methods:
- Review of clinical data correlating postprandial lipoproteins with cardiovascular disease.
- Analysis of mechanistic studies on lipoprotein remnant effects on endothelium.
- Examination of lipid exchange and hemostatic variable changes during lipemia.
Main Results:
- Postprandial lipoproteins correlate with coronary artery disease and carotid intimal thickness.
- Lipoprotein remnants adversely affect endothelium and subendothelial space.
- Lipid exchange leads to smaller, denser LDL particles and lower HDL cholesterol.
- Hemostatic variables may increase during postprandial lipemia.
Conclusions:
- Postprandial lipemia poses a significant risk for atherogenesis.
- Assessment and treatment of atherosclerosis should incorporate postprandial lipemia parameters.