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Determination of zopiclone in plasma using column liquid chromatography with ultraviolet detection
M J Royer-Morrot1, M Rambourg, I Jacob
1Service de Pharmacologie Clinique et Toxicologie, Hopital Central, Nancy, France.
Journal of Chromatography
|October 23, 1992
Abstract:
A reversed-phase liquid chromatographic method with ultraviolet detection for the determination of zopiclone in plasma is described. It is rapid, sensitive, reproducible and linear over a wide range. The method was used to study plasma zopiclone concentrations in a case of acute intoxication after oral ingestion of 300 mg of the drug. The plasma level was 1600 ng/ml 4.5 h after the dose and the elimination half-life was 3.5 h.