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Related Experiment Videos

Is adenovirus a fetal pathogen?

Ahmet A Baschat1, Jeffrey Towbin, Neil E Bowles

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Advanced Fetal Care, University of Maryland, Baltimore 21201, USA. aabaschat@hotmail.com

American Journal of Obstetrics and Gynecology
|October 4, 2003
PubMed
Summary

Adenovirus genetic material in amniotic fluid was detected in pregnancies with central nervous system anomalies and echogenic liver foci. Further research is needed to understand the significance of adenovirus in adverse pregnancy outcomes.

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Area of Science:

  • Maternal-fetal medicine
  • Viral infections in pregnancy
  • Prenatal diagnostics

Background:

  • Adenovirus infections during pregnancy can potentially impact fetal development.
  • Detecting viral genetic material in amniotic fluid may offer insights into fetal exposure.
  • Understanding the association between adenovirus and adverse pregnancy outcomes is crucial for clinical management.

Purpose of the Study:

  • To investigate the relationship between adenovirus presence in amniotic fluid and adverse pregnancy outcomes.
  • To determine if adenovirus detection in amniotic fluid is associated with specific fetal abnormalities.

Main Methods:

  • Prospective, observational study of pregnant women in their second trimester.
  • Multiplex polymerase chain reaction (PCR) used to detect adenovirus in amniotic fluid samples.

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  • Exclusion of fetuses with abnormal karyotypes from the analysis.

    • Main Results:

    • Adenovirus prevalence was similar in normal and anomalous fetuses, with significant seasonal variation.
    • Central nervous system anomalies and echogenic liver foci were more common in fetuses with detectable adenovirus.
    • No significant difference in the monthly rate of amniocentesis was observed.

    Conclusions:

    • Adenovirus is present in amniotic fluid of both normal and abnormal pregnancies with similar prevalence and seasonal patterns.
    • Echogenic liver lesions and neural tube defects were significantly more frequent in pregnancies with adenovirus.
    • The clinical significance of adenovirus detection in amniotic fluid warrants further investigation.