Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monoamine involvement in hippocampal self-stimulation.

D van der Kooy, H C Fibiger, A G Phillips

    Brain Research
    |November 4, 1977
    PubMed
    Summary

    Noradrenergic projections do not affect hippocampal self-stimulation. However, serotonin depletion via PCPA significantly reduces this behavior, indicating its crucial role in hippocampal reward pathways.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model.

    Biomaterials·2016
    Same author

    Acute stress impairs set-shifting but not reversal learning.

    Behavioural brain research·2013
    Same author

    Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

    Molecular psychiatry·2012
    Same author

    Facilitated extinction of morphine conditioned place preference with Tat-GluA2(3Y) interference peptide.

    Behavioural brain research·2012
    Same author

    Oscillatory power and synchrony in the rat forebrain are altered by a sensitizing regime of D-amphetamine.

    Neuroscience·2012
    Same author

    Single mammillary body cells with divergent axon collaterals. Demonstration by a simple, fluorescent retrograde double labeling technique in the rat.

    Brain research·2011

    Area of Science:

    • Neuroscience
    • Neuropharmacology
    • Behavioral Neuroscience

    Background:

    • The hippocampus plays a role in reward and motivation.
    • Noradrenergic and serotonergic systems are implicated in brain reward functions.

    Purpose of the Study:

    • To investigate the roles of noradrenergic and serotonergic projections in hippocampal intracranial self-stimulation (ICSS).
    • To determine the specific contributions of these neurotransmitter systems to reward processing in the hippocampus.

    Main Methods:

    • Lesioning of the dorsal tegmental noradrenergic bundle using 6-hydroxydopamine.
    • Administration of para-chlorophenylalanine (PCPA) to deplete serotonin.
    • Measurement of hippocampal and lateral hypothalamic ICSS in rats.
    • Biochemical assays to confirm neurotransmitter depletions.

    Main Results:

    • Noradrenergic bundle lesions did not alter hippocampal ICSS.
    • PCPA administration temporarily depleted brain serotonin and decreased hippocampal ICSS.
    • These serotonin depletions were paralleled by behavioral changes.
    • PCPA facilitated lateral hypothalamic ICSS, suggesting differential effects on brain regions.

    Conclusions:

    • Noradrenergic input is not essential for hippocampal self-stimulation.
    • Serotonergic projections are critical for maintaining hippocampal reward.
    • Findings challenge simple monoamine theories of reinforcement, highlighting regional specificity.

    Related Experiment Videos