Related Experiment Videos
Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats
Linda A Parker1, Raphael Mechoulam
1Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario. lparker@wlu.ca
Summary
Cannabinoids like delta-9-THC and CBD can reduce conditioned gaping in rats, a model for nausea. The endogenous cannabinoid system appears to play a role in controlling nausea responses.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Conditioned gaping in rats is a validated animal model for nausea.
- The endogenous cannabinoid system (ECS) is involved in various physiological processes, including appetite and pain perception.
Purpose of the Study:
- To investigate the effects of psychoactive and non-psychoactive cannabinoids on conditioned gaping in rats.
- To explore the role of the ECS in nausea using a conditioned gaping paradigm.
Main Methods:
- Rats were trained to associate a taste cue with nausea-inducing agents.
- Various cannabinoids, including delta-9-THC, HU-210, Cannabidiol (CBD), and CBD-dmh, were administered.
- The CB1 receptor antagonist SR-141716 was used to block cannabinoid effects and assess ECS involvement.
- Lithium chloride was used to induce nausea and conditioned gaping.
Main Results:
- All tested cannabinoids (delta-9-THC, HU-210, CBD, CBD-dmh) attenuated both the establishment and expression of conditioned gaping.
- The CB1 antagonist SR-141716 reversed the anti-nausea effects of HU-210.
- SR-141716 potentiated lithium-induced conditioned gaping, indicating ECS involvement.
Conclusions:
- Cannabinoids demonstrate anti-nausea properties in a rat model.
- The endogenous cannabinoid system plays a significant role in the regulation of nausea.