Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Translational Medicine: A two-way road.

Francesco M Marincola1

  • 1Immunogenetics Section, Clinical Center, Department of Transfusion Medicine, NIH, Bethesda MD, 20892, USA. fmarincola@mail.cc.nih.gov

Journal of Translational Medicine
|October 7, 2003
PubMed
Summary

Translational research bridges laboratory discoveries and clinical applications. Enhancing the "Bedside to Bench" pathway requires specialized review for human ex vivo studies, improving disease treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan.

Journal of translational medicine·2026
Same author

A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8<sup>+</sup> T Cells.

Journal of translational medicine·2026
Same author

Critical evaluation of compositions and clinical relevance of Wharton's jelly-derived biologics.

Journal of translational medicine·2026
Same author

Hierarchical therapeutic potential in the mesenchymal stem cell landscape.

Journal of translational medicine·2025
Same author

Reduction of solid tumors by senescent cell immunization.

Journal of translational medicine·2025
Same author

Inflammatory mitochondrial signalling and viral mimicry in cancer.

Journal of translational medicine·2025

Area of Science:

  • Biomedical Research
  • Clinical Science
  • Translational Medicine

Background:

  • Translational research facilitates testing novel therapies in humans.
  • It operates as a two-way process: "Bench to Bedside" and "Bedside to Bench."
  • The "Bedside to Bench" component is underdeveloped due to challenges in interdisciplinary understanding and human subject complexities.

Purpose of the Study:

  • To highlight the importance of "Bedside to Bench" translational research.
  • To advocate for increased publication of ex vivo human observations.
  • To propose improvements in the review process for translational research.

Main Methods:

  • The study is a conceptual review and proposal.
  • It emphasizes the need for specialized peer review for translational studies.
  • It discusses the integration of clinical and basic science perspectives.

Main Results:

  • Limited success in "Bedside to Bench" research is noted.
  • Journals are encouraged to publish ex vivo human observations.
  • A revised review process involving clinical scientists is proposed.

Conclusions:

  • Enhanced "Bedside to Bench" research can accelerate disease treatment.
  • Specialized review is crucial for studies involving human ex vivo data.
  • Integrating clinical realities with basic science is key to effective translational research.

Related Experiment Videos