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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Readmissions and the quality of care in patients hospitalized with heart failure
Jean-Christophe Luthi1, Mary Jo Lund, Laura Sampietro-Colom
1Institute of Social and Preventive Medicine, University of Lausanne, Switzerland. Jean-Christophe.Luthi@inst.hospvd.ch
Insights
Prescribing angiotensin-converting enzyme inhibitors (ACEI) at recommended doses for patients with heart failure and left ventricular systolic dysfunction (LVSD) is associated with fewer hospital readmissions. Adhering to guidelines improves patient outcomes.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Clinical guidelines recommend angiotensin-converting enzyme inhibitors (ACEI) for heart failure with left ventricular systolic dysfunction (LVSD).
- Optimal dosing of ACEI aims to reduce mortality and hospital readmissions.
Purpose of the Study:
- To investigate the association between ACEI use at discharge and subsequent readmission rates in LVSD patients.
- To evaluate adherence to ACEI prescribing guidelines in heart failure management.
Main Methods:
- Retrospective analysis of medical records from 611 eligible patients hospitalized for heart failure.
- Data abstracted on ACEI prescription at discharge (recommended dose, less than recommended, or none).
- Readmission rates assessed up to 21 months post-discharge.
Main Results:
- Patients not prescribed ACEI at discharge had a 1.74 times higher readmission rate (RR 1.74, 95% CI 1.22-2.48).
- Patients on sub-therapeutic ACEI doses had a 1.24 times higher readmission rate (RR 1.24, 95% CI 0.91-1.69).
- A significant trend (P=0.005) indicated lower readmissions with increasing ACEI dose adequacy.
Conclusions:
- ACEI use at discharge is linked to reduced readmission rates in LVSD patients.
- Compliance with ACEI prescribing guidelines for heart failure offers significant clinical benefits.
- Optimizing ACEI therapy is crucial for managing heart failure and preventing readmissions.
Objectives:
Clinical practice guidelines based on the results of randomized clinical trials recommend that patients with heart failure due to left ventricular systolic dysfunction (LVSD) be treated with angiotensin-converting enzyme inhibitors (ACEI) at doses shown to reduce mortality and readmission. This study examined the relationship between ACEI use at discharge and readmission among patients with heart failure due to LVSD.
Methods And Results:
Data were abstracted from the medical records of 2943 randomly selected patients hospitalized for heart failure in 50 hospitals. The outcome of interest was the number of readmissions occurring up to 21 months after discharge. Six-hundred and eleven patients were eligible for analysis. Compared with patients discharged at a recommended ACEI dose, patients not prescribed an ACEI at discharge had an adjusted rate ratio of readmission (RR) of 1.74 [95% confidence interval (CI) 1.22-2.48], while patients prescribed an ACEI at less than a recommended dose had an RR of 1.24 (95% CI 0.91-1.69) (P = 0.005 for the trend).
Conclusion:
Our results show that ACEI use at discharge in patients with LVSD is associated with decreased rate of readmission. These findings suggest that compliance with the ACEI prescribing recommendations listed in clinical practice guidelines for patients with heart failure due to LVSD confers benefit.
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