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Related Experiment Videos

Extracapsular radiation dose distribution after permanent prostate brachytherapy.

Gregory S Merrick1, Wayne M Butler, Kent E Wallner

  • 1Schiffler Cancer Center, Wheeling Hospital, Wheeling, West Virginia 26003-6300, USA. schifonc@wheelinghosp.com

American Journal of Clinical Oncology
|October 7, 2003
PubMed
Summary

This study shows that pre-planned margins in prostate brachytherapy effectively deliver radiation doses to the periprostatic region. The average 100% isodose margin achieved was 6.5 mm, exceeding the 5 mm planning goal.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Prostate brachytherapy is a treatment for low-risk prostate cancer.
  • Accurate radiation dose delivery to the periprostatic region is crucial for treatment efficacy and minimizing side effects.
  • Pre-planning margins are essential for ensuring adequate dose coverage.

Purpose of the Study:

  • To evaluate the physical extent of radiation dose delivered to the periprostatic region in patients undergoing prostate brachytherapy.
  • To assess the effectiveness of pre-planned periprostatic margins in achieving desired radiation dose distribution.

Main Methods:

  • A study of 26 patients with low-risk prostate cancer treated with 103Pd or 125I brachytherapy without external beam radiation.
  • Transrectal ultrasound and pre-planning based on a uniform seed-loading philosophy.

Related Experiment Videos

  • Day 0 CT-based dosimetric evaluation of isodose margins.

    • Main Results:

    • The overall mean 100% isodose margin was 6.5 mm ± 1.8 mm.
    • 125I and 103Pd isotopes showed similar 100% isodose margins (6.8 mm ± 1.6 mm and 6.3 mm ± 1.9 mm, respectively).
    • The 100% isodose margin met or exceeded 5.0 mm in most areas, confirming the utility of pre-planned margins.

    Conclusions:

    • Pre-planned periprostatic margins are strongly correlated with delivering prescription radiation doses to the target periprostatic region.
    • The achieved post-implant periprostatic margin of 6.5 mm satisfies the pre-planning criterion of >5 mm.
    • Prostate brachytherapy with pre-planned margins ensures adequate dose coverage in the periprostatic space.