Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulating histone acetyltransferases and deacetylases.

Gaëlle Legube1, Didier Trouche

  • 1Laboratoire de Biologie Moléculaire des Eucaryotes, UMR 5099 Centre National de la Recherche Scientifique, Institut d'Exploration Fonctionnelle des Génomes, 118 Route de Narbonne, 31062 Toulouse Cedex, France.

EMBO Reports
|October 7, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Control of DNA double-strand break repair by the KDM8 histone demethylase.

Cell cycle (Georgetown, Tex.)·2026
Same author

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability.

Molecular cell·2026
Same author

Circadian PERIOD proteins regulate TC-DSB repair through anchoring to the nuclear envelope.

Molecular cell·2025
Same author

Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks.

Nature cell biology·2025
Same author

Nuclear and genome dynamics underlying DNA double-strand break repair.

Nature reviews. Molecular cell biology·2025
Same author

Genome-wide profiling of DNA repair proteins in single cells.

Nature communications·2024

Histone acetyltransferases and histone deacetylases control cell fate by regulating protein acetylation. Their function is tightly controlled by cellular mechanisms influencing interactions with transcription factors.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are key epigenetic regulators.
  • These enzymes control gene expression through histone and transcription factor acetylation.
  • Dysregulation of HATs and HDACs is linked to various cellular processes and diseases.

Purpose of the Study:

  • To review the molecular mechanisms regulating HAT and HDAC activity.
  • To discuss how these regulatory events impact cellular responses.
  • To highlight the role of HATs and HDACs in cell fate determination.

Main Methods:

  • Literature review of recent findings on HAT and HDAC regulation.
  • Analysis of molecular mechanisms controlling enzyme levels, activity, and interactions.

Related Experiment Videos

  • Discussion of the functional consequences of regulatory events.

    • Main Results:

    • HAT and HDAC function is modulated by intricate cellular mechanisms.
    • Regulation occurs through changes in enzyme levels, catalytic activity, and protein-protein interactions.
    • These regulatory events are crucial for adapting cellular responses to environmental stimuli.

    Conclusions:

    • Tight regulation of HATs and HDACs is essential for maintaining cellular homeostasis.
    • Understanding these regulatory networks provides insights into cell fate control.
    • Further research into HAT and HDAC modulation can reveal therapeutic targets.