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Published on: August 13, 2020
[Aids in children: observations on vertical transmission]
1Laboratório de Imunologia Clínica, Departamento de Imunologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21045-900, Brasil.
Insights
This review covers pediatric acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) mother-to-infant transmission. It details how HIV infection occurs in utero, during, and after delivery.
Area of Science:
- Pediatric Infectious Diseases
- Epidemiology
- Virology
Context:
- Acquired immunodeficiency syndrome (AIDS) presents unique challenges in pediatric populations.
- Vertical transmission of human immunodeficiency virus (HIV) remains a critical global health concern.
Purpose:
- To review the epidemiological landscape of pediatric AIDS.
- To elucidate the mechanisms and routes of vertical HIV transmission from mother to child.
Summary:
- The paper examines the epidemiology of AIDS in children.
- It discusses various modes of mother-to-infant HIV transmission.
- Physiopathological aspects of in utero, intrapartum, and postpartum HIV infection are explored.
Impact:
- Informing public health strategies for pediatric HIV prevention and care.
- Enhancing understanding of HIV pathogenesis in neonates and children.
- Guiding interventions to reduce mother-to-child transmission rates.
Abstract:
This paper seeks to review the epidemiological aspects of the acquired immunodeficiency syndrome (AIDS) in children and the vertical transmission of the human immunodeficiency virus (HIV). The modes of mother-to-infant transmission are discussed, including physiopathological aspects of HIV infection in utero, during, and/or after delivery.
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