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Published on: July 21, 2013
[Ischemic insult in the anterior and posterior cerebral circulation]
Dzevdet Smajlović1, Omer Ibrahimagić, Zikrija Dostović
1Neuroloska klinika, Univerzitetski klinićki centar Tuzla, Medicinski fakultet Univerziteta u Tuzli.
Insights
Anterior circulation strokes (ACS) comprise 81.8% of ischemic strokes, predominantly affecting females who are older on average. Hospital mortality for both anterior and posterior circulation strokes is similar, but higher in females.
Area of Science:
- Neurology
- Epidemiology
- Vascular Medicine
Context:
- Clinical classifications of ischemic stroke often distinguish between anterior and posterior cerebral circulation events.
- Understanding the epidemiological characteristics of these stroke types is crucial for public health and clinical management.
Purpose:
- To analyze the frequency, age and sex distribution, risk factors, and hospital mortality of anterior circulation stroke (ACS) versus posterior circulation stroke (PCS).
Summary:
- This study analyzed 1772 acute ischemic stroke patients, finding ACS in 81.8% and PCS in 18.2%. Females were more prevalent and older in both groups. Hypertension, heart disease, and diabetes were common risk factors. Cortical lesions dominated ACS, while lacunar lesions were frequent in PCS. Hospital mortality was similar for ACS and PCS but significantly higher in females.
Impact:
- The findings highlight the predominance of ACS and the increased vulnerability of females to stroke, irrespective of circulation type.
- Identifies key risk factors and demographic trends in ischemic stroke, informing targeted prevention and treatment strategies.
- Provides data on hospital mortality, underscoring the need for gender-specific considerations in stroke care and research.
Abstract:
In the everyday practice among clinical and etiological classifications for ischemic stroke, the terms strokes in the anterior and posterior cerebral circulation are also in use. The aim of this study was to analyze the frequency of ischemic strokes in the anterior and posterior circulation, their age and sex distribution, risk factors and hospital mortality. In the study it was analyzed 1772 patients with acute ischemic stroke hospitalized at the Department of Neurology Tuzla, Bosnia and Herzegovina, between January 1st 1996 and December 31st 2000. The mean age was 65.5 years (+9.9), 942 (55%) were females. Ischemic strokes for all patients were confirmed with computed tomography, while other data were collected from the standard patients' history charts. Anterior circulation stroke (ACS) had 1408 patients (81.8%), the rest of 314 (18.2%) had posterior circulation stroke (PCS). In the both types females were slightly overrepresented: 784 (56%) in ACS, and 158 (50.5%) in PCS. Moreover, females were significantly older than males: 67 (+9.8) versus 64 (+10) years in ACS (p < 0.001), 67.5 (+10.3) versus 63.5 (+9.2) in PCS (p < 0.001). Hypertension was the major risk factor occurring in 67% patients with ACS and 71 with PCS; heart diseases 54% in the both types, and diabetes in 23% patients with ACS and 20% with PCS. The cortical ischemic lesion was verified in 46% patients with ACS, 41% with PCS; subcortical in 12.5% and 14.5%; and lacunar in 41.5% and 44.5%, respectively. Hospital mortality was 30% (430 patients) for ACS, and 32% (101 patients) for PCS. Hospital mortality was considerably higher among females: 33% versus 28% for ACS (p = 0.03), 38% versus 27% for PCS (p = 0.03). On the basis of our study we can conclude that ischemic strokes in the anterior cerebral circulation are 4/5 of all ischemic strokes at the Department of Neurology Tuzla. Both, anterior and posterior circulation strokes are more frequent in females, witches were in average older than males. The cortical lesion dominated in ACS, and lacunar in PCS. The distribution of risk factors (hypertension, heart diseases, and diabetes) is similar for ACS and PCS, and hospital mortality also; however, mortality rate is higher in females.
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