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Updated: Mar 25, 2026

Bergmeyer Glucose Quantification for Microbiological Samples

Bergmeyer Glucose Quantification for Microbiological Samples

Published on: January 17, 2025

Interferometric optical sensor for measuring glucose concentration.

Kun-Huang Chen¹, Cheng-Chih Hsu, Der-Chin Su

¹Institute of Electro-Optical Engineering, National Chiao Tung University, 1001 Ta-Hsueh Road, Hsin-Chu 300, Taiwan, China.

|October 8, 2003

Summary

This summary is machine-generated.

This study presents a novel surface-plasmon resonance (SPR) sensor for glucose monitoring. The sensor achieves high-resolution glucose concentration measurements using phase difference analysis, demonstrating its practical feasibility.

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Area of Science:

Optoelectronics
Biomedical Sensing
Surface Plasmon Resonance (SPR)

Background:

Accurate glucose monitoring is crucial for diabetes management.
Existing methods may have limitations in resolution or sample volume.
Surface-plasmon resonance offers a label-free detection principle.

Purpose of the Study:

To develop and validate a novel SPR-based sensor for glucose concentration measurement.
To assess the sensor's performance in terms of resolution and measurement range.

Main Methods:

Utilized a common-path heterodyne interferometer to measure the phase difference between s- and p-polarized light.
Employed a specially designed probe for surface-plasmon resonance excitation.
Correlated phase difference data with glucose concentration.

Main Results:

Demonstrated a feasible prototype sensor for glucose detection.
Achieved a measurement resolution of 1.41 mg/dl at 25°C.
Experimentally validated the sensor in the concentration range of 40-500 mg/dl using small sample volumes.

Conclusions:

The developed SPR sensor is capable of accurate and high-resolution glucose concentration estimation.
The sensor's design and performance suggest potential for practical applications in glucose monitoring.