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Updated: Aug 30, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Thymic atypical carcinoid with Cushing's syndrome manifesting in the terminal stage
Noritaka Isowa1, Takayuki Nakamura, Fumio Yamazaki
1Department of Thoracic Surgery, Shizuoka City Hospital, Shizuoka, Japan.
Abstract:
A 56-year-old man with recurrent thymic atypical carcinoid presented with Cushing's syndrome only in the terminal stage. Eighteen months after the resection of an anterior mediastinal mass, he presented with hypernatremia and hypokalemia with high serum levels of adrenocorticotropic hormone and cortisol, and died two months later. An autopsy demonstrated multiple metastases of the tumor to the mediastinum, lungs, heart, liver, kidneys, bone, pituitary gland, and ocular muscles. The adrenocorticotropic hormone level of the tumor tissue was 26,000 pg/g.
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