Muscarinic and nicotinic cholinergic agonists: structural analogies and discrepancies

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Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice
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Subcutaneous Administration of Muscarinic Antagonists and Triple-Immunostaining of the Levator Auris Longus Muscle in Mice

Published on: September 8, 2011

Zsolt Bikádi1, Miklós Simonyi

  • 1Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, P.O.B. 17, Budapest, H-1525 Hungary.

Current Medicinal Chemistry
|October 8, 2003
PubMed

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Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
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