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Updated: Aug 30, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
A comparison of calculated and experimental parameters as sources of structural information: the case of
Giulia Caron1, Giuseppe Ermondi
1Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via PGiuria 9, I-10125 Torino, Italy. giulia.caron@unito.it
Abstract:
This review is organized in three parts: firstly there is a general overview of recent developments in lipophilicity written to induce medicinal chemists to question what they want to obtain from this kind of study; secondly, the state-of-the-art of experimental and computational determination of log P is briefly reviewed; finally, some applications are discussed to illustrate how much information can be extracted from lipophilicity, and to highlight the difficulty of obtaining a reliable, general method to work with.
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