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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
AMPA glutamate receptors and neuropathic pain
Susana Morales-Alcelay1, Laura Rubio, Ana Martinez
1Neuropharma S. A. Avda. de la Industria 52, 28760 Tres Cantos, Spain.
Abstract:
Glutamate receptors are implicated in many actions in the central nervous system, as an excitatory amino acid, and one of the more relevant is its role in excitotoxicity. Apart from this, it also has a role as pro-nociceptive agent, so that antagonizing its actions could be of interest for developing new analgesic agents. Furthermore, between the analgesics agents, it is of outstanding interest the fact that there is no specific therapy against the neuropathic pain, and glutamate receptor subunits have elicited as new potential targets for this disturbance.
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