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Updated: Jul 25, 2026
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A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Direct laparoscopic venous sampling to diagnose a small Sertoli-Leydig tumor
L C White1, K D Buchanan, T D O'Leary
1Department of Obstetrics/Gynecology, Arnold Palmer Hospital, Orlando Regional Healthcare System, Orlando, FL 32806, USA.
Gynecologic Oncology
|October 8, 2003
Summary
Sertoli-Leydig cell tumors (SLCT) are rare ovarian neoplasms. This case highlights a unique diagnostic approach and the occurrence of a second primary SLCT in a teenage patient.
Area of Science:
- Gynecologic Oncology
- Endocrinology
- Surgical Innovation
Background:
- Sertoli-Leydig cell tumors (SLCT) are rare ovarian neoplasms, accounting for 0.5% of all primary ovarian tumors.
- Hyperandrogenism in adolescents necessitates thorough investigation for underlying causes, including rare ovarian neoplasms.
- Early and accurate diagnosis is crucial for effective management of ovarian tumors.
Observation:
- A 14-year-old female presented with symptoms of hyperandrogenism and elevated serum testosterone.
- Direct laparoscopic ovarian blood sampling confirmed the ovarian origin of testosterone excess.
- A subsequent contralateral ovarian tumor was diagnosed and treated three years after the initial presentation.
Findings:
- The patient was diagnosed with bilateral Sertoli-Leydig cell tumors (SLCT) of intermediate differentiation.
- Selective laparoscopic venous sampling proved effective in diagnosing a small, hormonally active SLCT.
- The patient underwent successful surgical management for both primary tumors and remains disease-free.
Implications:
- This case underscores the importance of considering rare ovarian tumors in adolescent hyperandrogenism.
- Direct laparoscopic venous sampling offers a valuable diagnostic tool for localized ovarian hormone production.
- The occurrence of bilateral SLCT highlights the need for vigilant long-term surveillance in affected patients.
