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The linear-quadratic model and fractionated stereotactic radiotherapy
Lizhong Liu1, Daniel A Bassano, Satish C Prasad
1Department of Radiation Oncology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA. liul@upstate.edu
International Journal of Radiation Oncology, Biology, Physics
|October 8, 2003
Summary
Clinicians can use lookup tables based on the linear-quadratic model to determine biologically equivalent doses per fraction for stereotactic radiotherapy. Simple rules of thumb are provided for two- and three-fraction treatments.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- Stereotactic radiotherapy, using Gamma Knife or linear accelerators, often involves single-fraction treatments.
- Fractionating these treatments requires careful dose planning to maintain biological equivalence.
Purpose of the Study:
- To establish a method for determining the optimal dose per fraction for multi-fraction stereotactic radiotherapy.
- To provide practical guidance for clinicians planning fractionated stereotactic treatments.
Main Methods:
- The linear-quadratic (LQ) model was employed to calculate biologically equivalent doses per fraction.
- Results were compiled into user-friendly lookup tables.
Main Results:
- Lookup tables provide biologically equivalent doses per fraction for various fraction numbers.
- For typical stereotactic doses and few fractions, the alpha/beta ratio's impact is minimal.
- A simplified rule suggests two-thirds and one-half of the single-fraction dose for two- and three-fraction treatments, respectively.
Conclusions:
- The generated tables serve as a valuable clinical guide for fractionated stereotactic treatment planning.
- The findings support the use of simplified dose calculations in specific clinical scenarios.
- Accurate dose per fraction determination is crucial for effective and safe stereotactic radiotherapy.