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Published on: October 20, 2011
Molecular genetic analysis of the virulence of oral bacterial pathogens: an historical perspective
1Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA. kuramits@buffalo.edu
Abstract:
This review will focus on the impact of molecular genetic approaches on elucidating the bacterial etiology of oral diseases from an historical perspective. Relevant results from the pre- and post-recombinant DNA periods will be highlighted, including the roles of gene cloning, mutagenesis, and nucleotide sequencing in this area of research. Finally, the impact of whole-genome sequencing on deciphering the virulence mechanisms of oral pathogens, along with new approaches to control these organisms, will be discussed.
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